听力与言语-语言病理学

行为科学

医学伦理学

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  • [Intracrinology and dehydroepiandrosterone--a new perspective for the use of androgens in hormone replacement therapy in postmenopausal women].

    abstract::During menopausal transition not only ovarian production of estrogens but also marked decrease of adrenal androgen production are observed Decreased secretion of adrenal DHEA and DHEA-S result in reduction of peripheral conversion of these steroids into active estrogens and androgens. Intracrinology describes the bios...

    journal_title:Ginekologia polska

    pub_type: 杂志文章,评审

    doi:

    authors: Perzyło K,Kulik-Rechberger B,Gałczyński K,Rechberger T

    更新日期:2011-09-01 00:00:00

  • [Obtaining the Impact Factor by Ginekologia Polska].

    abstract::Scientific journals are ranked and evaluated to measure their relative importance and influence on science within a specific field. One of the tools most widely used to evaluate and compare journals is the Thomson Reuters Impact Factor In Poland a specific value of a scientist's Impact Factor is required for academic ...

    journal_title:Ginekologia polska

    pub_type: 社论

    doi:

    authors: Spaczyński M,Januszek-Michalecka L,Nowak-Markwitz E,Kedzia W,Spaczyński R,Karowicz-Bilińska A

    更新日期:2011-08-01 00:00:00

  • [Obstetric consequences of uncontrolled gestational diabetes--a case study].

    abstract::This paper presents a case of a pregnant woman who was admitted to the obstetrics and gynecology department because of a new onset of uncontrolled diabetes in 27 weeks gestation. The maternal and fetal diabetic complications suggested a chronic character of the disease which must have been undiagnosed before pregnancy...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Murlewska J,Pietryga M,Bagnosz-Magnuszewska A,Zawiejska A,Brazert J,Gadzinowski J,Wender-Ozegowska E

    更新日期:2011-08-01 00:00:00

  • [Gap junction intercellular communication in carcinogenesis of endometrial cancer].

    abstract::One of the mechanisms for direct cell to cell signaling is mediated by gap junctions. These junctions are formed by connexins, transmembrane proteins. Gap junction intercellular communication (GJIC) plays a critical role in tissue development, differentiation of cells, and regulation of tissue homeostasis. Cancer cell...

    journal_title:Ginekologia polska

    pub_type: 杂志文章,评审

    doi:

    authors: Baltaziak M,Kańczuga-Koda L,Rutkowski R,Musiatowicz M,Koda M,Leśniewicz R,Sulkowska U,Baltaziak M,Leśniewicz T,Sulkowski S

    更新日期:2011-07-01 00:00:00

  • SDF-1alpha/CXCL12 and dendritic cells in ovarian cancer microenvironment.

    abstract:AIM:To evaluate the a-chemokine stromal cell-derived factor-1 (SDF-1)/CXCL12 levels in the peritoneal fluid (PF) and plasma of patients with epithelial ovarian cancer (EOC, n=101), serous cyst (n=34) or normal controls (n=20). SDF-1alpha concentrations were correlated to myeloid (M) and lymphoid (L) dendritic cells (DC...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Wertel I,Polak G,Tarkowski R,Kotarska M

    更新日期:2011-06-01 00:00:00

  • Placenta praevia increta with caesarean section scar invasion.

    abstract:INTRODUCTION:Placenta increta refers to the placenta invading the myometrium. It is a rare but life-threatening condition. The incidence of placenta increta ranges widely from 1 in 540 to 1 in 93,000 deliveries; in Poland it is approximately 0.2% of all deliveries. The occurrence of placenta praevia increta is much low...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Izabela UW,Krzysztof N,Ryszard P,Aneta P

    更新日期:2011-06-01 00:00:00

  • [Treatment of cervical pregnancy with systemic methotrexate and KCI solution injection into the gestational sac--case report and review of literature].

    abstract::We report a case of a 6-week cervical pregnancy successfully treated with systemic methotrexate and gestational sac biopsy with 15%-calcium chloride solution injection. Serial monitoring of human chorionic gonadotropin levels, combined with ultrasound examinations, confirmed spontaneous miscarriage. Applied treatment ...

    journal_title:Ginekologia polska

    pub_type: 杂志文章,评审

    doi:

    authors: Polak G,Stachowicz N,Morawska D,Kotarski J

    更新日期:2011-05-01 00:00:00

  • [Bladder pain syndrome--an urological-gynecological problem].

    abstract::Bladder Pain Syndrome remains a great challenge for urologists, both in diagnostics and treatment. Etiopathogenesis of the disease is unknown. It is reported that the reason for Bladder Pain Syndrome is the urothelium dysfunction resulting in the destruction of the protective glycosaminoglycan layer/barrier protecting...

    journal_title:Ginekologia polska

    pub_type: 杂志文章,评审

    doi:

    authors: Zabkowski T,Bortnowski L,Zieliński H

    更新日期:2011-03-01 00:00:00

  • Cyclopia--literature review and a case report.

    abstract::Cyclopia is a deformation of the facial skeleton with one eye orbit formed in the place where both eyes should be present. As a result of hypoplasia there is absence (hypothesized loss) of central nervous system structures. Teratogenic factors leading to the occurrence of this anomaly may include irregular cholesterol...

    journal_title:Ginekologia polska

    pub_type: 杂志文章,评审

    doi:

    authors: Olejek A,Bodzek P,Skutil M,Zamłyński J,Stołtny P

    更新日期:2011-03-01 00:00:00

  • [Insertion of IUD after extrauterine mislocation of the previous one].

    abstract::We present a case report of a 37-year-old woman with accidental finding of two IUDs--one inserted correctly and the other one located in the abdomen. ...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Lewandowski J,Cieminski A,Emerich J

    更新日期:2011-02-01 00:00:00

  • Usefulness of the Apgar score: a national survey of Polish neonatal centers.

    abstract:INTRODUCTION:The paper discusses the reliability of the Apgar score for evaluating newborns, particularly its usefulness in assessing the state of preterm or full term newborns born with hypoxia. AIM:The paper provides a sum-up of the opinions on usefulness and reliability of the Apgar score given by doctors from 255 ...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Kornacka MK,Musialik-Swietlińska E,Swietliński J,Ksiazyk J,Migdał M,Brozek G,Zejda J

    更新日期:2011-01-01 00:00:00

  • Positive correlation between serum omentin and thrombospondin-1 in gestational diabetes despite lack of correlation with insulin resistance indices.

    abstract:UNLABELLED:Gestational Diabetes (GDM) is characterized by insulin resistance and a pro-inflammatory state, both factors possible related to adipokine expression. SUBJECTS AND METHODS:The study included 20 women with GDM, diagnosed according to the WHO criteria, and 23 matched for age and BMI women with normal glucose ...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Lewandowski K,Nadel I,Lewinski A,Bienkiewicz M,Tan B,Randeva HS,Cypryk K

    更新日期:2010-12-01 00:00:00

  • [Subchorionic hematoma as a risk factor of pregnancy and delivery in women with threatening abortion].

    abstract:OBJECTIVES:The aim was to present pregnancy complications and outcome in the group of women with subchorionic hematoma (SCH) diagnosed in the first or second trimester of pregnancy METHODS:A retrospective study was performed to compare the perinatal outcome of 41 patients with SCH (study group) with 59 women treated o...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Biesiada L,Krekora M,Krasomski G

    更新日期:2010-12-01 00:00:00

  • [Vaginal and cervical bacterial colonization in patients with threatening preterm labor].

    abstract:OBJECTIVES:The aim of the following work was to evaluate vaginal and cervical colonization in patients with threatening preterm labor and comparing the frequency of colonization of the term and preterm labor groups. MATERIAL AND METHODS:532 pregnant women with threatening preterm labor were included into the clinical ...

    journal_title:Ginekologia polska

    pub_type: 临床试验,杂志文章

    doi:

    authors: Czajka R,Rzepka R,Kwiatkowski S,Torbe A,Swiszczowska A,Mikołajek-Bedner W,Chłapowska E,Łodziato-Kheder M,Sokołowska M,Jaroszewicz A,Marcinkiewicz O,Zapałowska M

    更新日期:2010-11-01 00:00:00

  • [Growing importance of the Polish Gynaecology--comments of the editorial team].

    abstract::The Impact Factor is a measure of average citation frequency for articles in a specific scientific journal during a specific period of time. IF takes into account the content, sources, layout and frequency and regularity of publishing. In order to get an impact factor, a journal needs to be first put on the Philadelph...

    journal_title:Ginekologia polska

    pub_type: 社论

    doi:

    authors: Spaczyński M,Januszek-Michalecka L,Nowak-Markwitz E,Kedzia W,Spaczyński R,Karowicz-Bilińska A

    更新日期:2010-10-01 00:00:00

  • [Expert panel recommendations on therapeutic and diagnostic management of urinary incontinence and overactive bladder in women].

    abstract::The expert panel recommendations are issued in order to increase the number of patients with urinary incontinence and overactive bladder receiving appropriate care. The expert panel recommends that urologists, gynecologists and other physicians interested in the field of incontinence should Incontinence question shoul...

    journal_title:Ginekologia polska

    pub_type: 杂志文章,实务指引

    doi:

    authors: Radziszewski P,Baranowski W,Nowak-Markwitz E,Rechbeger T,Suzin J,Witek A,Expert Panel.

    更新日期:2010-10-01 00:00:00

  • [Flow cytometry application in the evaluation of antisperm antibodies in sera samples of infertile people and prepubertal boys with gonadal disorders].

    abstract:OBJECTIVES:The aim of the following study was to assess antisperm antibodies in sera samples of infertile men and women, as well as from prepubertal boys by means of flow cytometry. MATERIAL AND METHODS:We tested sera samples of infertile and fertile adult populations, prepubertal boys with gonadal disorders and healt...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Kamieniczna M,Havryluk A,Nakonechnyj A,Boyko J,Chopyak V,Kurpisz M

    更新日期:2010-08-01 00:00:00

  • Prospective clinical study of the association between plasma level of free IGF-1 and myometrial invasion min patients with endometrial adenocarcinoma.

    abstract:INTRODUCTION:Endometrial carcinoma is a common malignancy of the female genital tract. There is a strong correlation between myometrial invasion and clinical prognosis. Increasing myometrial penetration is associated with an increasing risk of pelvic and para-aortic lymph node metastasis, adnexal metastasis, positive p...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Baloglu A,Bezircioglu I,Cetinkaya B,Hicyilmaz L

    更新日期:2010-07-01 00:00:00

  • Prognostic significance of VEGF and its receptors in endometrioid endometrial cancer.

    abstract:BACKGROUND:Angiogenesis is of crucial importance for endometrial tumor growth and Vascular Endothelial Growth Factor (VEGF) is the key mediator of angiogenesis. OBJECTIVE:The purpose of our study was to assess the prognostic value of VEGF and its receptors in relation to endometrioid endometrial carcinomas. MATERIAL ...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Dobrzycka B,Terlikowski SJ,Kwiatkowski M,Garbowicz M,Kinalski M,Chyczewski L

    更新日期:2010-06-01 00:00:00

  • Adult stem cells therapy for urine incontinence in women.

    abstract::The past few years brought high development in obtaining and culturing autologous adult stem cells. In this paper we review publications of experimental investigations and clinical trials of the muscle-derived cells and the application in the treatment of stress urinary incontinence among women. Mesenchymal stem cells...

    journal_title:Ginekologia polska

    pub_type: 杂志文章,评审

    doi:

    authors: Stangel-Wójcikiewicz K,Majka M,Basta A,Stec M,Pabian W,Piwowar M,Chancellor MB

    更新日期:2010-05-01 00:00:00

  • [The impact of premature rupture of membranes (PROM) on neonatal outcome].

    abstract:OBJECTIVE:The aim of the following study was to evaluate the impact of premature rupture of membranes (PROM) on neonatal outcome, particularly on the incidence of intrauterine infections (IUI). MATERIAL AND METHODS:The study included 428 newborns, born after PROM and hospitalized in the Department of Neonatology at Po...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Plucińska A,Hajduczenia M,Pastusiak M,Kowalik M,Miechowicz I,Szymankiewicz M

    更新日期:2010-04-01 00:00:00

  • [Levels of immunoreactive cytokines in serum of women with preeclampsia or severe pregnancy hypertension].

    abstract:OBJECTIVE:The purpose of the study was to compare concentrations of inflammatory and Th1/Th2 cytokines in serum obtained from women with preeclampsia or severe pregnancy hypertension versus normotensive controls. MATERIAL AND METHODS:The study group consisted of 34 pregnant women with hypertension over 140/90mmHg and ...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Tarnowska-Madra U,Leibschang J,Kowalska B,Filipp E,Kozar A,Nimer A,Maciejewski T

    更新日期:2010-03-01 00:00:00

  • [Tocolytic therapy in threatened preterm labor].

    abstract::The most important benefit of tocolysis is a 48-hour prolongation of gestational age in order to administer corticosteroids to reduce perinatal mortality and morbidity as well as, if necessary to gain time for "in utero" transfer to a tertiary centre with neonatal facilities. The tocolytic agents used in clinical prac...

    journal_title:Ginekologia polska

    pub_type: 杂志文章,评审

    doi:

    authors: Kimber-Trojnar Z,Leszczyńska-Gorzelak B,Marciniak B,Bartosiewicz J,Oleszczuk J

    更新日期:2010-02-01 00:00:00

  • [Gene therapy applications in gynecologic malignances management].

    abstract::Gene therapy is an innovative way of treating genetic disorders, which enables removal or repair of genetic defects. Strategies of gene therapy offer new perspectives in treating cancer diseases. Numerous methods for specifically removing tumor cells are currently used. They can be divided into five main strategies: c...

    journal_title:Ginekologia polska

    pub_type: 杂志文章,评审

    doi:

    authors: Gromadzka A,Kubiczak M,Jankowska A

    更新日期:2010-01-01 00:00:00

  • [Physiological and pathological consequences of a presence of germ line stem cells in adult tissues].

    abstract::Various therapheutic strategies employing stem cells have been proposed as the alternative, effective methods for therapy of multitude diseases, difficult to treat using standard, well-established methods. Advancing regenerative medicine, which is becoming a novel branch of clinical medicine, has high hopes of stem ce...

    journal_title:Ginekologia polska

    pub_type: 杂志文章,评审

    doi:

    authors: Ratajczak MZ,Machaliński B,Czajka R,Zuba-Surma E,Poziomkowska-Gesicka I,Słowik-Zyłka D

    更新日期:2009-12-01 00:00:00

  • [Noninvasive prenatal test in the first trimester of pregnancy (NT and estimation of beta-hCG and PAPP-A) in the diagnosis of fetal abnormalities in Polish population--comparison of the biochemistry own normal ranges and literature reported data].

    abstract:THE AIM OF STUDY:Estimation of Polish population standards of the concentrations of pregnancy-associated plasma protein--A (PAPP-A) and free beta--human chorionic gonadotropin (beta-HCG) in the maternal blood between 10.0 and 13.6 week of pregnancy and comparison of the biochemistry own normal ranges and literature rep...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Mandryka-Stankewycz S,Perenc M,Dec G,Sieroszewski P

    更新日期:2009-11-01 00:00:00

  • [Emergency and elective cesarean section and selected elements of immunological system of full-term neonates].

    abstract:AIM OF STUDY:To define a relationship between emergency and elective indications for cesarean section and quantitative changes of percentage and quantity of T and B lymphocytes and their subpopulations in healthy full-term neonates. MATERIAL AND METHODS:The study included 43 healthy neonates born in the years 1998 - 2...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Echolc B,Mazur B,Królak-Olejnik B,Kwiecińska M,Karpe J,Grzonka D

    更新日期:2009-10-01 00:00:00

  • [Assessment of three-level selective perinatal care based on the analysis of early perinatal death rates and cesarean sections in Poland in 2008].

    abstract:AIM:The aim of the following work was to assess three-level selective perinatal care in Polish voivodeships in 2008 on the basis of the following parameters: birth rates as well as perinatal death rates, divided into three classes of neonatal weights, in hospitals on each of the three levels. The goal of selective peri...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Troszyński M,Niemiec T,Wilczyńska A

    更新日期:2009-09-01 00:00:00

  • [Analysis of risk factors for nosocomial infections in the Neonatal Intensive Care Unit of the Pomeranian Medical University in Szczecin in the years 2005-2008].

    abstract:UNLABELLED:The aim of the study was to assess the significance of some perinatal risk factors and neonatal complications in occurrence of nosocomial infections in the population of NICU patients. MATERIAL AND METHODS:Analysis of risk factors was performed in all patients treated in the years 2005-2008 in NICU Departme...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Elster T,Beata Czeszyńska M,Sochaczewska D,Konefał H,Baryła-Pankiewicz E

    更新日期:2009-08-01 00:00:00

  • [The statement of Polish Gynaecologic Society experts concerning drinking water consumption in women in reproductive age, pregnancy and breast feeding].

    abstract::Water is a substance essential for life. It creates the environment of our body, keeps it's homeostasis, enables every biochemical reaction and metabolic processes in human organism. Maternal hydratation is essential for homeostasis of two organisms and drinking water influences the amniotic fluid volume, fetal well-b...

    journal_title:Ginekologia polska

    pub_type: 指南,杂志文章,实务指引

    doi:

    authors: Tomasz N,Polish Gynaecological Society.

    更新日期:2009-07-01 00:00:00

  • [Activin A as a possible marker for hypoxia and intraventricular haemorrhage in newborns].

    abstract::The article presents general information about activin A, a glycoprotein that belongs to the transforming growth factor beta superfamily. Structure, mechanism and role of activin as a possible marker of hypoxia and intraventricular haemorrhage were described. ...

    journal_title:Ginekologia polska

    pub_type: 杂志文章,评审

    doi:

    authors: Fiala M,Baumert M,Walencka Z

    更新日期:2009-06-01 00:00:00

  • Ruptured ectopic pregnancy mimicking acute pancreatitis.

    abstract:INTRODUCTION:Ectopic pregnancy may lead to massive haemorrhage, infertility or death. Prompt diagnosis and treatment are crucial to save patients who would otherwise die. Serum amylase and lipase measurements are known biochemical markers of pancreatic inflammation and a recognized finding that may help diagnose acute ...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Mitura K,Romanczuk M

    更新日期:2009-05-01 00:00:00

  • [The possibility of cardiovascular system evaluation in fetuses at 11.0 to 13.6 weeks of gestation in a reference perinatal cardiology centre].

    abstract:OBJECTIVE:To assess the possibility of foetal circulatory system evaluation between 11+0 to 13+6 weeks of gestation in a reference perinatal cardiology centre. MATERIAL AND METHODS:A prospective study was conducted between January 2004 and June 2008 in patients admitted to the reference perinatal cardiology centre for...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Własienko P,Hamela-Olkowska A,Jalinik K,Dangel J

    更新日期:2009-04-01 00:00:00

  • [Evaluation of the embryonic and foetal heart rate at 6(+0) to 11(+6) weeks of gestation].

    abstract:OBJECTIVE:To establish the normal range of embryonic heart rate (EHR) and foetal heart rate (FHR) at 6(+0) to 11(+6) weeks of gestation, to evaluate the risk of pregnancy loss depending on EHR and FHR values and to establish if checking of FHR with the use of M-mode method is possible in different levels obstetric depa...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Hamela-Olkowska A,Wiech K,Jalinik K,Zaryjewski D,Kornatowski L,Dangel J

    更新日期:2009-03-01 00:00:00

  • [Obstetric hysterectomy in a patient with uterine myoma of uterus duplex--case report].

    abstract::A case of a 43-year-old multipara in 36th week of pregnancy with a duplicate uterus and uterine myoma with 15 centimeters diameter has been presented in the article. The aim of the study was to present her obstetric history, course of pregnancy and delivery mode. ...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Kuś E,Swierczewski A,Orłowska K,Brzozowska M,Estemberg D,Berner-Trabska M,Kowalska-Koprek U,Karowicz-Bilińska A

    更新日期:2009-02-01 00:00:00

  • [Matrix metalloproteinases and their inhibitors in ovarian cancer progression--diagnostic and therapeutic implications].

    abstract::Matrix metalloproteinases are proteolytic enzymes which degrade extracellular matrix proteins. Along with their specific inhibitors--issue inhibitors of metalloproteinases--they play an important role in the spreading of malignant tumours. The research conducted in recent years has shown that metalloproteinases and th...

    journal_title:Ginekologia polska

    pub_type: 杂志文章,评审

    doi:

    authors: Stettner R,Bogusiewicz M,Rechberger T

    更新日期:2009-01-01 00:00:00

  • Total Prolift System surgery for treatment posthysterectomy vaginal vault prolapse--do we treat both anatomy and function?

    abstract:OBJECTIVES:To assess clinical efficacy of Total Prolift System surgery kit in the treatment of post hysterectomy vaginal vault prolapse. MATERIAL AND METHODS:Study group consisted of 27 women (mean age 60.3 +/- 10.3 years) who between February 2006 and September 2007 underwent vaginal cuff prolapse surgery with Total ...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Rechberger T,Futyma K,Bartuzi A

    更新日期:2008-12-01 00:00:00

  • [Gall bladder stones during pregnancy in the age of laparoscopic cholecystectomy].

    abstract::Not all pregnant women with gall bladder stones can be treated conservatively--some of them require surgery. The main indications for cholecystectomy are the following: repeated episodes of biliary colic and acute cholecystitis. There is no data indicating which moment during the pregnancy may be the safest to perform...

    journal_title:Ginekologia polska

    pub_type: 杂志文章,评审

    doi:

    authors: Modrzejewski A,Lewandowski K,Pawlik A,Czerny B,Kurzawski M,Juzyszyn Z

    更新日期:2008-11-01 00:00:00

  • [Fetal echocardiography in 83 fetuses with omphalocele from Dept. for Diagnoses and Prevention of Fetal Malformations, Research Institute Polish Mother's Memorial Hospital, and Medical University of Lodz, (1999-2006)].

    abstract:MATERIAL AND METHODS:It was a retrospective analysis of fetal echocardiography results (analysis of congenital heart defect (CHD) and functional abnormalities in normal heart anatomy) in 83 fetuses diagnosed and treated in the same institution. RESULTS:In our group of fetuses, the most common structural defect, in add...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Respondek-Liberska M,Papis A,Oszukowski P,Krasomski G,Maroszyńska I,Chilarski A,Wilczyński J

    更新日期:2008-09-01 00:00:00

  • [Thrombotic thrombocytopenic purpura in pregnancy. A case report].

    abstract::Thrombotic thrombocytopenic purpura (TTP) is characterized by microangiopathic hemolytic anemia and thrombocytopenia, accompanied by microvascular thrombosis that causes variable degrees of tissue ischemia and infarction. About 10-20% of TTP cases are associated with the pregnancy. Preterm delivery and intrauterine fe...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Treliński J,Perenc M,Sieroszewski P,Chojnowski K

    更新日期:2008-07-01 00:00:00

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